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While bare AuNPs rely primarily on enhanced permeability and retention (EPR) effects, surface functionalization with polymers like Gum Arabic or bioactive molecules like resveratrol improves tumor specificity and pharmacokinetic profiles [78, 79]

[33] In chronic inflammatory bowel diseases, including Crohns disease, systematic reviews (including Cochrane reviews) have concluded that current randomized evidence is insufficient to support glutamine supplementation for inducing remission or modifying disease progression, and further well-powered clinical trials are required

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Research designs that measure both local tissue concentrations and systemic pharmacokinetics help address this question